![]() These drugs are non-steroidal compounds that strongly blunt the aromatization of androgens. There are quite a few pharmaceutical aromatase inhibitors on the market, namely Arimidex (anastrozole), Aromasin (exemestane), Nolvadex (tamoxifen), and Femara (letrozole). In clinical settings, aromatase inhibitors are often used for treating the early stages of breast cancer in women and gynecomastia in men. Aromatase inhibitors reduce the conversion of testosterone into estrogen (estradiol) and androstenedione into estrone, the latter being a minor estrogenic hormone in men. How Do Estrogen Blockers Work?Įstrogen blockers typically act as aromatase inhibitors (AIs), meaning they bind to the aromatase enzyme and deactivate it. ![]() In fact, men with low estrogen often experience symptoms comparable to having too much estrogen, notably decreased sex drive. Men need small amounts of estrogen for proper health and longevity. However, most men incorrectly assume that estrogen is inherently a "bad hormone" when it's actually quite the opposite. But when a sudden influx of estrogen cars swarm the parking lot, they "steal" those androgen vehicles' parking spots.Įssentially, high estrogen levels prevent testosterone and other androgens from working their anabolic magic by occupying those precious parking spots (read: receptor binding sites). Normally, only a handful of these spots are "reserved" for estrogen the rest are for androgens like testosterone and DHT. Estradiol and other estrogenic hormones compete for the same androgen receptors as androgens, and each androgen receptor only has so many binding sites available for these hormones to occupy.Īs an analogy, think of the androgen receptor like a parking lot with a limited amount of open spaces for estrogenic and androgenic vehicles. When a man has high testosterone levels, he won’t feel very "alpha" if estrogen levels are also sharply elevated.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |